The failure of antimotion sickness medication to improve reading in developmental dyslexia: results of a randomized trial.

TitleThe failure of antimotion sickness medication to improve reading in developmental dyslexia: results of a randomized trial.
Publication TypeJournal Article
Year of Publication1988
AuthorsFagan, JE, Kaplan, BJ, Raymond, JE, Edgington, ES
JournalJ Dev Behav Pediatr
Volume9
Issue6
Pagination359-66
Date Published1988 Dec
ISSN0196-206X
KeywordsChild, Double-Blind Method, Dyslexia, Eye Movements, Female, Humans, Male, Meclizine, Methylphenidate, Postural Balance, Psychomotor Performance, Random Allocation, Reading, Saccades
Abstract

Although there have been no randomized clinical trials of the efficacy of antimotion sickness medication treatment of developmental dyslexia, some children are treated in this way. We have performed two evaluations of such treatments. In Experiment 1, 12 children participated in a double-blind within-subject crossover design to test the acute (2-day) administration of four preparations: 10 mg methylphenidate, 12.5 mg meclizine, both methylphenidate and meclizine, or placebo. Improvements obtained with each drug were scattered across measures of reading fluency, balance and coordination, and eye movements, suggesting that a chronic trial would be justified. In Experiment 2, six children from Experiment 1 received 12.5 mg meclizine b.i.d. for 3 months and placebo for 3 months in a double-blind within-subject crossover design. Meclizine had no effect on reading, but it significantly improved ocular motor stability during steady fixation. This study thus failed to support the hypothesis that meclizine is of benefit in developmental dyslexia.

Alternate JournalJ Dev Behav Pediatr
PubMed ID3220956

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